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Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression

Nimbolide, an active chemical constituent of Azadirachta indica, reportedly has several physiological effects. Here, we assessed novel anticancer effects of nimbolide against bladder cancer EJ and 5637 cells. Nimbolide treatment inhibited the proliferation of both bladder cancer cell lines with an I...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Evid Based Complement Alternat Med
Prif Awduron: Shin, Seung-Shick, Hwang, Byungdoo, Muhammad, Kashif, Gho, Yujeong, Song, Jun-Hui, Kim, Wun-Jae, Kim, Gonhyung, Moon, Sung-Kwon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662486/
https://ncbi.nlm.nih.gov/pubmed/31391858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3753587
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