Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression

We previously reported that hydrangenol has potent antitumor activity against human bladder cancer EJ cells. Here, we investigated the antiangiogenic activity of hydrangenol using in vitro and ex vivo models. Treatment with hydrangenol significantly inhibited the proliferation of vascular endothelia...

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Bibliographic Details
Published in:Anim Cells Syst (Seoul)
Main Authors: Gho, Yujeong, Shin, Seung-Shick, Choi, Yung Hyun, Ko, Kisung, Kim, Wun-Jae, Moon, Sung-Kwon
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
Subjects:
Molecular & Cellular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440517/
https://ncbi.nlm.nih.gov/pubmed/30949393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19768354.2019.1578262
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