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Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression

Background: Cutaneous melanoma is a highly malignant tumor which tends to metastasize in the early stage and leads to poor prognosis. Hematogenous and lymphatic metastasis are common in the dissemination of melanoma. Rapamycin, an mTOR inhibitor, was reported to have anti-angiogenic and anti-lymphan...

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Dettagli Bibliografici
Pubblicato in:Onco Targets Ther
Autori principali: Wang, Min, Xu, Yuan, Wen, Guo-Zhong, Wang, Qian, Yuan, Si-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580124/
https://ncbi.nlm.nih.gov/pubmed/31354297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S205160
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