Inhibition of VEGF(165)/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis

Hepatocellular carcinoma (HCC) relies on angiogenesis for growth and metastasis. Leukocyte cell-derived chemotaxin 2 (LECT2) is a cytokine and preferentially expressed in the liver. Previous studies have found that LECT2 targets to both immune and tumor cells to suppress HCC development and vascular...

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Udgivet i:Sci Rep
Main Authors: Chen, Chi-Kuan, Yu, Wen-Hsuan, Cheng, Tsu-Yao, Chen, Min-Wei, Su, Chia-Yi, Yang, Yi-Chieh, Kuo, Tsang-Chih, Lin, Ming-Tsan, Huang, Ya-Chi, Hsiao, Michael, Hua, Kuo-Tai, Hung, Mien-Chie, Kuo, Min-Liang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979047/
https://ncbi.nlm.nih.gov/pubmed/27507763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31398
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