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Gene expression models based on transcription factor binding events confer insight into functional cis-regulatory variants

MOTIVATION: Deciphering the functional roles of cis-regulatory variants is a critical challenge in genome analysis and interpretation. It has been hypothesized that altered transcription factor (TF) binding events are a central mechanism by which cis-regulatory variants impact gene expression levels...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Shi, Wenqiang, Fornes, Oriol, Wasserman, Wyeth W
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662294/
https://ncbi.nlm.nih.gov/pubmed/30541050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty992
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