Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-(13)C] Lactate

The PI3K/AKT/mTOR (PAM) signaling pathway is frequently mutated in prostate cancer. Specific AKT inhibitors are now in advanced clinical trials, and this study investigates the effect of MK2206, a non–ATP-competitive inhibitor, on the cellular metabolism of prostate cancer cells. We observed a reduc...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Tee, Sui Seng, Suster, Izabela, Truong, Steven, Jeong, Sangmoo, Eskandari, Roozbeh, DiGialleonardo, Valentina, Alvarez, Julio A., Aldeborgh, Hannah N., Keshari, Kayvan R.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662159/
https://ncbi.nlm.nih.gov/pubmed/29330287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0458
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