USP8 Deubiquitinates the Leptin Receptor and Is Necessary for Leptin-Mediated Synapse Formation

Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Bland, Tyler, Sahin, Gulcan Semra, Zhu, Mingyan, Dillon, Crystal, Impey, Soren, Appleyard, Suzanne M, Wayman, Gary A
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660906/
https://ncbi.nlm.nih.gov/pubmed/31199479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00107
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