Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP

Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal hippocampal dendritic spine formation and synaptogenesis. Although leptin has been shown to induce synaptogenesis in the hypothalamus, its effects on...

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Main Authors: Dhar, Matasha, Zhu, Mingyan, Impey, Soren, Lambert, Talley J., Bland, Tyler, Karatsoreos, Ilia N., Nakazawa, Takanobu, Appleyard, Suzanne M., Wayman, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075163/
https://ncbi.nlm.nih.gov/pubmed/24877561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1332
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