Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP

Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal hippocampal dendritic spine formation and synaptogenesis. Although leptin has been shown to induce synaptogenesis in the hypothalamus, its effects on...

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Detalhes bibliográficos
Main Authors: Dhar, Matasha, Zhu, Mingyan, Impey, Soren, Lambert, Talley J., Bland, Tyler, Karatsoreos, Ilia N., Nakazawa, Takanobu, Appleyard, Suzanne M., Wayman, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075163/
https://ncbi.nlm.nih.gov/pubmed/24877561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1332
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