Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics

Several next-generation (universal) influenza vaccines and broadly neutralizing antibodies (bNAbs) are in clinical development. Some of these mediate inhibitions of virus replication at the postentry stage or use Fc-dependent mechanisms. Nonneutralizing antibodies have the potential to mediate enhan...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Winarski, Katie L., Tang, Juanjie, Klenow, Laura, Lee, Jeehyun, Coyle, Elizabeth M., Manischewitz, Jody, Turner, Hannah L., Takeda, Kazuyo, Ward, Andrew B., Golding, Hana, Khurana, Surender
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660725/
https://ncbi.nlm.nih.gov/pubmed/31296560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821317116
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