Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells

BACKGROUND: AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin has not been defined. METHODS: We used a variety of methods such as cell viabilit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Cell Int
Main Authors: Zhu, Jian, Zou, Hanhui, Yu, Wei, Huang, Yuluan, Liu, Bing, Li, Tao, Liang, Chengzhen, Tao, Huimin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Primary Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660702/
https://ncbi.nlm.nih.gov/pubmed/31372095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0896-9
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