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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is uniquely susceptible to rapid ubiquitin-mediated degradation in macrophages, fu...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6660195/ https://ncbi.nlm.nih.gov/pubmed/31282857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46043 |
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