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Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation

Interleukin-15 (IL15) is one of the most important cytokines currently being considered for cancer therapy applications. It is thought that by administering IL15 in complex with its cognate receptor alpha chain (IL15Rα) its biological activity could be increased manifold. We produced a fusion protei...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Schmid, Anja Sophie, Neri, Dario
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660064/
https://ncbi.nlm.nih.gov/pubmed/31348785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219313
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