Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2

Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal-recessive loss-of-function mutations in the ADA2 gene (previously known as CECR1) results in a systemic vasculitis known as deficiency of ADA2 (DADA2). Neutrophils and a subset of neutrophils known as low-density granulocytes (LDGs)...

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Pubblicato in:Blood
Autori principali: Carmona-Rivera, Carmelo, Khaznadar, Sami S., Shwin, Kyawt W., Irizarry-Caro, Jorge A., O’Neil, Liam J., Liu, Yudong, Jacobson, Kenneth A., Ombrello, Amanda K., Stone, Deborah L., Tsai, Wanxia L., Kastner, Daniel L., Aksentijevich, Ivona, Kaplan, Mariana J., Grayson, Peter C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Phagocytes, Granulocytes, and Myelopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659253/
https://ncbi.nlm.nih.gov/pubmed/31015188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018892752
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