Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2

Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal-recessive loss-of-function mutations in the ADA2 gene (previously known as CECR1) results in a systemic vasculitis known as deficiency of ADA2 (DADA2). Neutrophils and a subset of neutrophils known as low-density granulocytes (LDGs)...

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發表在:Blood
Main Authors: Carmona-Rivera, Carmelo, Khaznadar, Sami S., Shwin, Kyawt W., Irizarry-Caro, Jorge A., O’Neil, Liam J., Liu, Yudong, Jacobson, Kenneth A., Ombrello, Amanda K., Stone, Deborah L., Tsai, Wanxia L., Kastner, Daniel L., Aksentijevich, Ivona, Kaplan, Mariana J., Grayson, Peter C.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2019
主題:
Phagocytes, Granulocytes, and Myelopoiesis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659253/
https://ncbi.nlm.nih.gov/pubmed/31015188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018892752
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