Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2

Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal-recessive loss-of-function mutations in the ADA2 gene (previously known as CECR1) results in a systemic vasculitis known as deficiency of ADA2 (DADA2). Neutrophils and a subset of neutrophils known as low-density granulocytes (LDGs)...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood
मुख्य लेखकों: Carmona-Rivera, Carmelo, Khaznadar, Sami S., Shwin, Kyawt W., Irizarry-Caro, Jorge A., O’Neil, Liam J., Liu, Yudong, Jacobson, Kenneth A., Ombrello, Amanda K., Stone, Deborah L., Tsai, Wanxia L., Kastner, Daniel L., Aksentijevich, Ivona, Kaplan, Mariana J., Grayson, Peter C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2019
विषय:
Phagocytes, Granulocytes, and Myelopoiesis
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659253/
https://ncbi.nlm.nih.gov/pubmed/31015188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018892752
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