Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

BACKGROUND: Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antigenic alterations occur during viral vaccine strain production, an inherent risk...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Joe, Patrick Tjok, Christopoulou, Ioanna, van Hoecke, Lien, Schepens, Bert, Ysenbaert, Tine, Heirman, Carlo, Thielemans, Kris, Saelens, Xavier, Aerts, Joeri L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659201/
https://ncbi.nlm.nih.gov/pubmed/31345237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1991-3
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