Multiple Copies of qnrA1 on an IncA/C(2) Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

In a previous study, mutants with enhanced ciprofloxacin resistance (Cip(r)) were selected from Escherichia coli J53/pMG252 carrying qnrA1. Strain J53 Cip(r) 8-2 showed an increase in the copy number and transcription level of qnrA1. We sequenced the plasmids on Illumina and MinION platforms. Parent...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Vinué, Laura, Sater, Mohamad R. A., Herriott, Ian, Huntley, Miriam H., Jacoby, George A., Hooper, David C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658789/
https://ncbi.nlm.nih.gov/pubmed/31160282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00718-19
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