Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum

Mutations in the Plasmodium falciparum k13 (Pfk13) gene are linked to delayed parasite clearance in response to artemisinin-based combination therapies (ACTs) in Southeast Asia. To explore the evolutionary rate and constraints acting on this gene, k13 orthologs from species sharing a recent common a...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Pacheco, M. Andreína, Kadakia, Esha R., Chaudhary, Zainab, Perkins, Douglas J., Kelley, Julia, Ravishankar, Shashidhar, Cranfield, Michael, Talundzic, Eldin, Udhayakumar, Venkatachalam, Escalante, Ananias A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Epidemiology and Surveillance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658766/
https://ncbi.nlm.nih.gov/pubmed/31085516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02550-18
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