Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum

Mutations in the Plasmodium falciparum k13 (Pfk13) gene are linked to delayed parasite clearance in response to artemisinin-based combination therapies (ACTs) in Southeast Asia. To explore the evolutionary rate and constraints acting on this gene, k13 orthologs from species sharing a recent common a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pacheco, M. Andreína, Kadakia, Esha R., Chaudhary, Zainab, Perkins, Douglas J., Kelley, Julia, Ravishankar, Shashidhar, Cranfield, Michael, Talundzic, Eldin, Udhayakumar, Venkatachalam, Escalante, Ananias A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658766/
https://ncbi.nlm.nih.gov/pubmed/31085516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02550-18
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