Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane voltage

Nanopore DNA sequencing is limited by low base calling accuracy. Improved base-calling accuracy has so far relied on specialized base-calling algorithms, different nanopores and motor enzymes, or biochemical methods to re-read DNA molecules. Two primary error modes hamper sequencing accuracy: enzyme...

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Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Noakes, Matthew T, Brinkerhoff, Henry, Laszlo, Andrew H, Derrington, Ian M, Langford, Kyle W, Mount, Jonathan W, Bowman, Jasmine L, Baker, Katherine S, Doering, Kenji M, Tickman, Benjamin I, Gundlach, Jens H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658736/
https://ncbi.nlm.nih.gov/pubmed/31011178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0096-0
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