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Differential binding affinity of tau repeat region R2 with neuronal-specific β-tubulin isotypes
Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6658543/ https://ncbi.nlm.nih.gov/pubmed/31346240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47249-7 |
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