Structure based drug design and machine learning approaches for identifying natural inhibitors against the human αβIII tubulin isotype

Abstract Microtubules (MTs) play a crucial role in mitosis and are composed of α-/β-tubulin heterodimeric subunits. In eukaryotes, eight α-tubulin and ten β-tubulin isotypes have been reported, each displaying tissue-specific expression patterns. Among them, the βIII-tubulin isotype is significantly...

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Hlavní autoři:	Pruthanka Anant Patil, Bajarang Vasant Kumbhar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-09-01
Edice:	Scientific Reports
Témata:	βIII-tubulin Cancer Virtual screening Machine learning AdaBoost algorithm Molecular dynamics simulation
On-line přístup:	https://doi.org/10.1038/s41598-025-17708-5
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