Hyperpolarizing Concentrated Metronidazole (15)NO(2) Group Over Six Chemical Bonds with More Than 15% Polarization and 20 Minute Lifetime

NMR hyperpolarization of uniformly (15)N-labeled metronidazole-(15)N(3) is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei). In this antibiotic, a (15)NO(2) group is hyperpolarized via spin relays created by (15)N spin...

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Publicado en:Chemistry
Main Authors: Shchepin, Roman V., Birchall, Jonathan R., Chukanov, Nikita V., Kovtunov, Kirill V., Koptyug, Igor V., Theis, Thomas, Warren, Warren S., Gelovani, Juri G., Goodson, Boyd M., Shokouhi, Sepideh, Rosen, Matthew S., Yen, Yi-Fen, Pham, Wellington, Chekmenev, Eduard Y.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658333/
https://ncbi.nlm.nih.gov/pubmed/30964568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201901192
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