(15)N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole via Reversible Parahydrogen Exchange in Microtesla Magnetic Fields

Nimorazole belongs to the imidazole-based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [(15)N(3)]nimorazole as a...

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Salnikov, Oleg G., Chukanov, Nikita V., Svyatova, Alexandra, Trofimov, Ivan A., Kabir, Mohammad S. H., Gelovani, Juri G., Kovtunov, Kirill V., Koptyug, Igor V., Chekmenev, Eduard Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855180/
https://ncbi.nlm.nih.gov/pubmed/33063407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011698
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