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(15)N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole via Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Nimorazole belongs to the imidazole-based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [(15)N(3)]nimorazole as a...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855180/ https://ncbi.nlm.nih.gov/pubmed/33063407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011698 |
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