(15)N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole via Reversible Parahydrogen Exchange in Microtesla Magnetic Fields

Nimorazole belongs to the imidazole-based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [(15)N(3)]nimorazole as a...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Salnikov, Oleg G., Chukanov, Nikita V., Svyatova, Alexandra, Trofimov, Ivan A., Kabir, Mohammad S. H., Gelovani, Juri G., Kovtunov, Kirill V., Koptyug, Igor V., Chekmenev, Eduard Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855180/
https://ncbi.nlm.nih.gov/pubmed/33063407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011698
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