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Quantifying immune-based counterselection of somatic mutations
Somatic mutations in protein-coding regions can generate ‘neoantigens’ causing developing cancers to be eliminated by the immune system. Quantitative estimates of the strength of this counterselection phenomenon have been lacking. We quantified the extent to which somatic mutations are depleted in p...
Tallennettuna:
| Julkaisussa: | PLoS Genet |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6657826/ https://ncbi.nlm.nih.gov/pubmed/31344031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008227 |
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