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Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η
Oxaliplatin, together with cisplatin, is among the most important drugs used in cancer chemotherapy. Oxaliplatin, which contains a bulky diaminocyclohexane (DACH) moiety, kills cancer cells mainly by producing (DACH)Pt-GpG intrastrand cross-links that impede transcription. The Pt-GpG tolerance by tr...
Shranjeno v:
| izdano v: | Biochem J |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6657808/ https://ncbi.nlm.nih.gov/pubmed/30709915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180848 |
| Oznake: |
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