Caricamento...

Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η

Oxaliplatin, together with cisplatin, is among the most important drugs used in cancer chemotherapy. Oxaliplatin, which contains a bulky diaminocyclohexane (DACH) moiety, kills cancer cells mainly by producing (DACH)Pt-GpG intrastrand cross-links that impede transcription. The Pt-GpG tolerance by tr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Biochem J
Autori principali: Ouzon-Shubeita, Hala, Baker, Meghan, Koag, Myong-Chul, Lee, Seongmin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657808/
https://ncbi.nlm.nih.gov/pubmed/30709915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180848
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !