Carregant...
Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion
The cisplatin-1,2-d(GpG) (Pt-GG) intrastrand cross-link is the predominant DNA lesion generated by cisplatin. Cisplatin has been shown to predominantly induce G to T mutations and Pt-GG permits significant misincorporation of dATP by human DNA polymerase β (polβ). In agreement, polβ overexpression,...
Guardat en:
| Publicat a: | Biochem J |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7534533/ https://ncbi.nlm.nih.gov/pubmed/32039434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190906 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|