Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease

Telomere shortening is associated with stem cell decline, fibrotic disorders and premature aging through mechanisms that are incompletely understood. Here, we show that telomere shortening in livers of telomerase knockout mice leads to a p53 - dependent repression of all seven sirtuins. P53 regulate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: Amano, Hisayuki, Chaudhury, Arindam, Rodriguez-Aguayo, Cristian, Lu, Lan, Akhanov, Viktor, Catic, Andre, Popov, Yury V., Verdin, Eric, Johnson, Hannah, Stossi, Fabio, Sinclair, David A., Nakamaru-Ogiso, Eiko, Lopez-Berestein, Gabriel, Chang, Jeffrey T., Neilson, Joel R., Meeker, Alan, Finegold, Milton, Baur, Joseph A., Sahin, Ergun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657508/
https://ncbi.nlm.nih.gov/pubmed/30930169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.001
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