Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease

Telomere shortening is associated with stem cell decline, fibrotic disorders and premature aging through mechanisms that are incompletely understood. Here, we show that telomere shortening in livers of telomerase knockout mice leads to a p53 - dependent repression of all seven sirtuins. P53 regulate...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Amano, Hisayuki, Chaudhury, Arindam, Rodriguez-Aguayo, Cristian, Lu, Lan, Akhanov, Viktor, Catic, Andre, Popov, Yury V., Verdin, Eric, Johnson, Hannah, Stossi, Fabio, Sinclair, David A., Nakamaru-Ogiso, Eiko, Lopez-Berestein, Gabriel, Chang, Jeffrey T., Neilson, Joel R., Meeker, Alan, Finegold, Milton, Baur, Joseph A., Sahin, Ergun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657508/
https://ncbi.nlm.nih.gov/pubmed/30930169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.001
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