Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma()()

A subset of poor-prognosis medulloblastoma has genomic amplification of MYC. MYC regulates glutamine metabolism in multiple cellular contexts. We modified the glutamine analog 6-diazo-5-oxo-l-norleucine (DON) to mask its carboxylate and amine functionalities, creating a prodrug termed JHU-083 with i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Hanaford, Allison R., Alt, Jesse, Rais, Rana, Wang, Sabrina Z., Kaur, Harpreet, Thorek, Daniel L.J., Eberhart, Charles G., Slusher, Barbara S., Martin, Allison M., Raabe, Eric H.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2019
Fag:
Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657308/
https://ncbi.nlm.nih.gov/pubmed/31340195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.05.013
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker