Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance

BACKGROUND: Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer prog...

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Bibliographic Details
Published in:World J Clin Oncol
Main Authors: Daley-Brown, Danielle, Harbuzariu, Adriana, Kurian, Ann Anu, Oprea-Ilies, Gabriela, Gonzalez-Perez, Ruben Rene
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2019
Subjects:
Basic Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657217/
https://ncbi.nlm.nih.gov/pubmed/31367531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5306/wjco.v10.i6.222
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