Cardioprotective Effects of Sphingosine-1-Phosphate Receptor Immunomodulator FTY720 in a Clinically Relevant Model of Cardioplegic Arrest and Cardiopulmonary Bypass

Objective: FTY720, an immunomodulator derived from sphingosine-1-phosphate, has recently demonstrated its immunomodulatory, anti-inflammatory, anti-oxidant, anti-apoptotic and anti-inflammatory properties. Furthermore, FTY720 might be a key pharmacological target for preconditioning. In this preclin...

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Udgivet i:Front Pharmacol
Main Authors: Ahmed, Naseer, Mehmood, Adeela, Linardi, Daniele, Sadiq, Soban, Tessari, Maddalena, Meo, Sultan Ayoub, Rehman, Rehana, Hajjar, Waseem M., Muhammad, Nazeer, Iqbal, Muhammad Perwaiz, Gilani, Anwar-ul-Hassan, Faggian, Giuseppe, Rungatscher, Alessio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656862/
https://ncbi.nlm.nih.gov/pubmed/31379576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00802
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