Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the TRPM7 ion channel is the critical mechanosensor, which directs decision-making...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Zhao, Runchen, Afthinos, Alexandros, Zhu, Tian, Mistriotis, Panagiotis, Li, Yizeng, Serra, Selma A., Zhang, Yuqi, Yankaskas, Christopher L., He, Shuyu, Valverde, Miguel A., Sun, Sean X., Konstantopoulos, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656542/
https://ncbi.nlm.nih.gov/pubmed/31355337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7243
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