Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

The transient receptor potential canonical subfamily member 5 (TRPC5), one of seven mammalian TRPC members, is a nonselective calcium-permeant cation channel. TRPC5 is of considerable interest as a drug target in the treatment of progressive kidney disease, depression, and anxiety. Here, we present...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Duan, Jingjing, Li, Jian, Chen, Gui-Lan, Ge, Yan, Liu, Jieyu, Xie, Kechen, Peng, Xiaogang, Zhou, Wei, Zhong, Jianing, Zhang, Yixing, Xu, Jie, Xue, Changhu, Liang, Bo, Zhu, Lan, Liu, Wei, Zhang, Cheng, Tian, Xiao-Li, Wang, Jianbin, Clapham, David E., Zeng, Bo, Li, Zongli, Zhang, Jin
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656536/
https://ncbi.nlm.nih.gov/pubmed/31355338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7935
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