Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic(1–8). Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env transitions from a pre-triggered conformation (...

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Publicado en:Nature
Main Authors: Lu, Maolin, Ma, Xiaochu, Castillo-Menendez, Luis R., Gorman, Jason, Alsahafi, Nirmin, Ermel, Utz, Terry, Daniel S., Chambers, Michael, Peng, Dongjun, Zhang, Baoshan, Zhou, Tongqing, Reichard, Nick, Wang, Kevin, Grover, Jonathan R., Carman, Brennan P., Gardner, Matthew R., Nikic-Spiegel, Ivana, Sugawara, Akihiro, Arthos, James, Lemke, Edward A., Smith, Amos B., Farzan, Michael, Abrams, Cameron, Munro, James B., McDermott, Adrian B., Finzi, Andrés, Kwong, Peter D., Blanchard, Scott C., Sodroski, Joseph G., Mothes, Walther
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6655592/
https://ncbi.nlm.nih.gov/pubmed/30971821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1101-y
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