Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

Cancer specific inhibitors reflective of unique metabolic needs, are rare. We describe a novel small molecule, Gboxin, that specifically inhibits primary mouse and human glioblastoma (GBM) cell growth but not mouse embryo fibroblasts or neonatal astrocytes. Gboxin rapidly and irreversibly compromise...

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Gepubliceerd in:Nature
Hoofdauteurs: Shi, Yufeng, Lim, S. Kyun, Liang, Qiren, Iyer, Swathi V., Wang, Hua-Yu, Wang, Zilai, Xie, Xuanhua, Sun, Daochun, Chen, Yu-Jung, Tabar, Viviane, Gutin, Philip, Williams, Noelle, De Brabander, Jef K., Parada, Luis F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6655586/
https://ncbi.nlm.nih.gov/pubmed/30842654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0993-x
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