Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling

Aims: Autophagy is a catabolic process required for the maintenance of cardiac health. Insulin and insulin-like growth factor 1 (IGF-1) are potent inhibitors of autophagy and as such, one would predict that autophagy will be increased in the insulin-resistant/diabetic heart. However, autophagy is ra...

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Udgivet i:Antioxid Redox Signal
Main Authors: Pires, Karla Maria, Torres, Natalia S., Buffolo, Marcio, Gunville, River, Schaaf, Christin, Davis, Kathryn, Selzman, Craig H., Gottlieb, Roberta A., Boudina, Sihem
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2019
Fag:
Forum Original Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6653796/
https://ncbi.nlm.nih.gov/pubmed/31088290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2018.7640
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