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Activation of IGF-1 Receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

Autophagy plays an important role in the maintenance of normal heart function. However, the role of autophagy in the inulin resistant and diabetic heart is not well understood. Furthermore, the upstream signaling and the downstream targets involved in cardiac autophagy regulation during obesity and...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Pires, Karla Maria, Buffolo, Marcio, Schaaf, Christin, Symons, J. David, Cox, James, Abel, E. Dale, Selzman, Craig H., Boudina, Sihem
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689477/
https://ncbi.nlm.nih.gov/pubmed/28987875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.10.001
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