INSULIN SUPPRESSES ISCHEMIC PRECONDITIONING-MEDIATED CARDIOPROTECTION THROUGH AKT-DEPENDENT MECHANISMS

It is believed that the diabetic myocardium is refractory to cardioprotection by ischemic preconditioning (IPC) mainly because of impaired insulin signaling to posphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB or Akt). However, human as well as animal studies have clearly showed that hea...

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Autori principali: Fullmer, Tanner M., Pei, Shaobo, Zhu, Yi, Sloan, Crystal, Manzanares, Robert, Henrie, Brandon, Pires, Karla M., Cox, James E., Abel, E. Dale, Boudina, Sihem
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835741/
https://ncbi.nlm.nih.gov/pubmed/23994159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.08.005
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