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Activation of IGF-1 Receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

Autophagy plays an important role in the maintenance of normal heart function. However, the role of autophagy in the inulin resistant and diabetic heart is not well understood. Furthermore, the upstream signaling and the downstream targets involved in cardiac autophagy regulation during obesity and...

詳細記述

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書誌詳細
出版年:J Mol Cell Cardiol
主要な著者: Pires, Karla Maria, Buffolo, Marcio, Schaaf, Christin, Symons, J. David, Cox, James, Abel, E. Dale, Selzman, Craig H., Boudina, Sihem
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689477/
https://ncbi.nlm.nih.gov/pubmed/28987875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.10.001
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