Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused by activated fibroblasts and myofibroblasts. Epithelial‐mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial f...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zhou, Jiajun, Cheng, Hong, Wang, Zijie, Chen, Hao, Suo, Chuanjian, Zhang, Hengcheng, Zhang, Jiayi, Yang, Yanhao, Geng, Liang, Gu, Ming, Tan, Ruoyun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6653435/
https://ncbi.nlm.nih.gov/pubmed/31140729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14420
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