Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused by activated fibroblasts and myofibroblasts. Epithelial‐mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial f...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Zhou, Jiajun, Cheng, Hong, Wang, Zijie, Chen, Hao, Suo, Chuanjian, Zhang, Hengcheng, Zhang, Jiayi, Yang, Yanhao, Geng, Liang, Gu, Ming, Tan, Ruoyun
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6653435/
https://ncbi.nlm.nih.gov/pubmed/31140729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14420
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