Cargando...

The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis. Here, we found that TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl)-2-thienyl]acetic acid) was a novel inhibitor for GlmU acety...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Front Cell Infect Microbiol
Main Authors: Chen, Changming, Han, Xiuyan, Yan, Qiulong, Wang, Chao, Jia, Liqiu, Taj, Ayaz, Zhao, Lizhe, Ma, Yufang
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652808/
https://ncbi.nlm.nih.gov/pubmed/31380295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2019.00251
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!