NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis

Pneumonia and sepsis are distinct but integrally linked public health concerns. The hepatic acute-phase response (APR), which is largely dependent on transcription factors NF-κB RelA and STAT3, is a hallmark of these pathologies and other injurious conditions. Inactivation of the APR can promote liv...

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Vydáno v:Infect Immun
Hlavní autoři: Kim, Yuri, Allen, Eri, Baird, Lillia A., Symer, Elise M., Korkmaz, Filiz T., Na, Elim, Odom, Christine V., Jones, Matthew R., Mizgerd, Joseph P., Traber, Katrina E., Quinton, Lee J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652780/
https://ncbi.nlm.nih.gov/pubmed/31160364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00132-19
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