Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is st...

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Detalhes bibliográficos
Main Authors: Quinton, Lee J., Blahna, Matthew T., Jones, Matthew R., Allen, Eri, Ferrari, Joseph D., Hilliard, Kristie L., Zhang, Xiaoling, Sabharwal, Vishakha, Algül, Hana, Akira, Shizuo, Schmid, Roland M., Pelton, Stephen I., Spira, Avrum, Mizgerd, Joseph P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336975/
https://ncbi.nlm.nih.gov/pubmed/22466650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59408
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