Systemic upregulation of IL-10 using a non-immunogenic vector reduces growth and rate of dissecting abdominal aortic aneurysm

OBJECTIVE: Recruitment of immunological competent cells to the vessel wall is a crucial step in formation of abdominal aortic aneurysms (AAA). Innate immunity effectors (e.g., macrophages), as well as mediators of adaptive immunity (e.g., T cells), orchestrate a local vascular inflammatory response....

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Adam, Matti, Kooreman, Nigel, Jagger, Ann, Wagenhaeuser, Markus U., Mehrkens, Dennis, Wang, Yongming, Kayama, Yosuke, Toyama, Kensuke, Raaz, Uwe, Schellinger, Isabel N., Maegdefessel, Lars, Spin, Joshua M., Hamming, Jaap F., Quax, Paul H.A., Baldus, Stephan, Wu, Joseph C., Tsao, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652227/
https://ncbi.nlm.nih.gov/pubmed/29880489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310672
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