Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes

RATIONALE: Accelerated arterial stiffening is a major complication of diabetes with no specific therapy available up to date. OBJECTIVE: The present study investigates the role of the osteogenic transcription factor Runx2 as a potential mediator and therapeutic target of aortic fibrosis and aortic s...

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Publicat a:Circ Res
Autors principals: Raaz, Uwe, Schellinger, Isabel N., Chernogubova, Ekaterina, Warnecke, Christina, Kayama, Yosuke, Penov, Kiril, Hennigs, Jan K., Salomons, Florian, Eken, Suzanne, Emrich, Fabian C., Zheng, Wei H., Adam, Matti, Jagger, Ann, Nakagami, Futoshi, Toh, Ryuji, Toyama, Kensuke, Deng, Alicia, Buerke, Michael, Maegdefessel, Lars, Hasenfuß, Gerd, Spin, Joshua M., Tsao, Philip S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553105/
https://ncbi.nlm.nih.gov/pubmed/26208651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.306341
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