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Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes

RATIONALE: Accelerated arterial stiffening is a major complication of diabetes with no specific therapy available up to date. OBJECTIVE: The present study investigates the role of the osteogenic transcription factor Runx2 as a potential mediator and therapeutic target of aortic fibrosis and aortic s...

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Bibliographische Detailangaben
Veröffentlicht in:Circ Res
Hauptverfasser: Raaz, Uwe, Schellinger, Isabel N., Chernogubova, Ekaterina, Warnecke, Christina, Kayama, Yosuke, Penov, Kiril, Hennigs, Jan K., Salomons, Florian, Eken, Suzanne, Emrich, Fabian C., Zheng, Wei H., Adam, Matti, Jagger, Ann, Nakagami, Futoshi, Toh, Ryuji, Toyama, Kensuke, Deng, Alicia, Buerke, Michael, Maegdefessel, Lars, Hasenfuß, Gerd, Spin, Joshua M., Tsao, Philip S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553105/
https://ncbi.nlm.nih.gov/pubmed/26208651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.306341
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