Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations. These mutations in specific genes generate premature termination codons (PTCs) respons...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Campofelice, Ambra, Lentini, Laura, Di Leonardo, Aldo, Melfi, Raffaella, Tutone, Marco, Pace, Andrea, Pibiri, Ivana
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651739/
https://ncbi.nlm.nih.gov/pubmed/31284579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133329
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