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Design, Synthesis and Biological Evaluation of Novel Osimertinib-Based HDAC and EGFR Dual Inhibitors

Herein a novel series of histone deacetylases (HDACs) and epidermal growth factor receptor (EGFR) dual inhibitors were designed and synthesized based on the structure of the approved EGFR inhibitor osimertinib (AZD9291). Among them, four compounds 5D, 5E, 9D and 9E exhibited more potent total HDAC i...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Dong, Hang, Yin, Hao, Zhao, Chunlong, Cao, Jiangying, Xu, Wenfang, Zhang, Yingjie
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651501/
https://ncbi.nlm.nih.gov/pubmed/31261881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24132407
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