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N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins
Hypochlorous acid (HOCl), a powerful antimicrobial oxidant, is produced by neutrophils to fight infections. Here, we show that N-chlorination, induced by HOCl concentrations encountered at sites of inflammation, converts blood plasma proteins into chaperone-like holdases that protect other proteins...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6650281/ https://ncbi.nlm.nih.gov/pubmed/31298656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47395 |
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